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・ Hereditary inclusion body myopathy
・ Hereditary intestinal polyposis
・ Hereditary Kingdom of Norway
・ Hereditary leiomyomatosis and renal cell cancer syndrome
・ Hereditary leiomyomatosis and renal cell carcinoma
・ Hereditary monarchy
・ Hereditary motor and sensory neuropathy
・ Hereditary motor and sensory neuropathy with proximal dominance
・ Hereditary mucoepithelial dysplasia
・ Hereditary multiple exostoses
・ Hereditary neuralgic amyotrophy
・ Hereditary neuropathy with liability to pressure palsy
・ Hereditary nonpolyposis colorectal cancer
・ Hereditary officers of the Roman Curia
・ Hereditary Order of Descendants of Colonial Governors
Hereditary pancreatitis
・ Hereditary peer
・ Hereditary Peerage Association
・ Hereditary persistence of fetal hemoglobin
・ Hereditary politicians
・ Hereditary Prince of Monaco
・ Hereditary Princes of Modena
・ Hereditary Princesses of Modena
・ Hereditary progressive mucinous histiocytosis
・ Hereditary property
・ Hereditary pyropoikilocytosis
・ Hereditary Quartermaster General of the Sacred Apostolic Palace
・ Hereditary Revenues Act 1856
・ Hereditary ring
・ Hereditary sclerosing poikiloderma


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Hereditary pancreatitis : ウィキペディア英語版
Hereditary pancreatitis

Hereditary pancreatitis (HP) is an inflammation of the pancreas, attributed to genetic causes. It was first described in 1952 by Comfort and Steinberg but it was not until 1996 that Whitcomb ''et al'' isolated the first responsible mutation in the trypsinogen gene (''PRSS1'') on the long arm of chromosome seven (''7q35'').
The term "hereditary pancreatitis" is used when a genetic biomarker is identified, and "familial pancreatitis" otherwise.
==Presentation==
HP is characterised by attacks of epigastric pain, which are often associated with nausea and vomiting. Symptoms may start shortly after birth but onset varies periodically, with some patients not exhibiting symptoms until adulthood. There is usually progression to chronic pancreatitis with endocrine and exocrine failure and a mortally increased risk of pancreatic cancer. Lifetime risk of cancer has been variously calculated as 35–54% to the age of 75 years and screening for early pancreatic cancer is being offered to HP sufferers on a scientific basis. Some patients may choose to have their pancreas surgically removed to prevent pancreatic cancer from developing in the future.
The epidemiology of HP follows a similar pattern to alcohol-associated chronic pancreatitis, but there are important differences. For example, HP typically has an earlier age of pancreatitis onset; although malabsorption and diabetes mellitus occur at a later stage in the disease progression.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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